Title:
ヒト化抗ＣＤ１９キメラ抗原受容体を使用するがんの処置
Document Type and Number:
Japanese Patent JP7439002
Kind Code:
B2
Abstract:
The disclosure provides compositions and methods for treating diseases associated with expression of CD19. The disclosure also relates to chimeric antigen receptor (CAR) specific to CD19, vectors encoding the same, and recombinant T cells comprising the CD19 CAR. The disclosure also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD 19 binding domain.
Inventors:
BROGDON, Jennifer
Carl H.JUNE
LOEW, Andreas
Marcella Mose
John Scholar
Carl H.JUNE
LOEW, Andreas
Marcella Mose
John Scholar
Application Number:
JP2021026430A
Publication Date:
February 27, 2024
Filing Date:
February 22, 2021
Export Citation:
Assignee:
Novartis Age
The Trustees of the University of Pennsylvania
The Trustees of the University of Pennsylvania
International Classes:
C12N15/62; A61K39/395; A61P35/00; A61P35/02; A61P43/00; C07K14/705; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/13; C12N15/63
Domestic Patent References:
| JP2012518404A | ||||
| JP2012095654A |
Foreign References:
| WO2012079000A1 |
Other References:
Hematology 2012, 2012, p.143-151
Molecular Immunology, 1997, Vol.34, No.16-17, p.1157-1165
J Immunother., 2009, Vol.32, No.7, p.689-702
The Journal of Immunology, 2009, Vol.183, p.5563-5574
Molecular Immunology, 1997, Vol.34, No.16-17, p.1157-1165
J Immunother., 2009, Vol.32, No.7, p.689-702
The Journal of Immunology, 2009, Vol.183, p.5563-5574
Attorney, Agent or Firm:
Michiko Matsutani
Norifumi Tomita
Norifumi Tomita