Title:
カンナビネルジック脂質リガンド
Document Type and Number:
Japanese Patent JP2008515978
Kind Code:
A
Abstract:
One aspect of this disclosure relates generally to lipid compounds that exert diverse effects in the endocannabinoid system, such as regulating CB1 and CB2 receptor or moderating other bio-macromolecules within the endocannabinoid system. Some of the compounds showed improved receptor binding affinity, and/or improved receptor subtype selectivity, and improved bio-stability. Some of the compounds exhibit activities to regulate the enzymes that moderate the bio-disposal of endogenous cannabinoids, such as the fatty acid amide hydrolase (FAAH). Some of the compounds exhibit activities to inhibit the anandamide transporter. Other aspects of the invention are pharmaceutical preparations employing these ligands and methods of administering therapeutically effective amounts of the preparations to provide a physiological effect.
Inventors:
McRyanis Alexandros
Richen
Lou Dai
Richen
Lou Dai
Application Number:
JP2007536806A
Publication Date:
May 15, 2008
Filing Date:
October 12, 2005
Export Citation:
Assignee:
UNIVERSITY OF CONNECTICUT
International Classes:
C07C233/11; A61K31/16; A61K31/167; A61K31/26; A61K31/27; A61K31/277; A61K31/426; A61K31/4406; A61P1/08; A61P3/04; A61P9/00; A61P25/02; A61P25/14; A61P25/22; A61P27/06; A61P35/00; A61P43/00; C07C233/25; C07C235/28; C07C235/48; C07C235/50; C07C237/16; C07C247/12; C07C255/07; C07C271/16; C07C331/22; C07D213/75; C07D277/20; C07D277/46; C07D277/48
Attorney, Agent or Firm:
Katsuzo Asakura
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