Title:
CANNABINOID RECEPTOR MODULATORS
Document Type and Number:
Japanese Patent JP2022009408
Kind Code:
A
Abstract:
To provide cannabinoid receptor modulators.SOLUTION: The present invention relates to compounds of a specific formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to compounds of the specific formula Ia and pharmaceutical compositions thereof that modulate the activity of both the CB1 receptor and the CB2 receptor. The compounds and pharmaceutical compositions are for methods useful in treatment of: pain, such as bone and joint pain, muscle pain, dental pain, headache, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of treatment, and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation: age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; and Alzheimer's disease.SELECTED DRAWING: None
Inventors:
JONES ROBERT M
HAN SANGDON
LARS THORESEN
JUNG JAE-KYU
SONJA STRAH-PLEYNET
ZHU XIUWEN
XIONG YIFENG
YUE DAWEI
HAN SANGDON
LARS THORESEN
JUNG JAE-KYU
SONJA STRAH-PLEYNET
ZHU XIUWEN
XIONG YIFENG
YUE DAWEI
Application Number:
JP2021173078A
Publication Date:
January 14, 2022
Filing Date:
October 22, 2021
Export Citation:
Assignee:
ARENA PHARM INC
International Classes:
C07D231/54; A61K31/416; A61K31/4439; A61K31/497; A61K31/661; A61P19/02; A61P25/02; A61P25/04; A61P43/00; C07D401/04; C07D401/14; C07D403/04; C07D405/14; C07F9/09
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki