Title:
HDAC阻害剤としてのピペラジン結合を有するカルバミン酸化合物
Document Type and Number:
Japanese Patent JP4606027
Kind Code:
B2
Abstract:
This invention pertains to certain carbamic acid compounds which inhibit HDAC (histone deacetylase) activity of the following formula: The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and in the treatment of conditions mediated by HDAC, cancer, proliferative conditions, psoriasis, etc.
Inventors:
Watkins, Claire, Jay.
Romero-Martin, Maria-Rosario
Ritchie, James
Fin, Paul, W.
Calvinche, Ivers
Rosa, Ainers
Dikovska, Clara
Starchen Cove, Igor
Lorya, Dyna
Gailaite, Villa
Romero-Martin, Maria-Rosario
Ritchie, James
Fin, Paul, W.
Calvinche, Ivers
Rosa, Ainers
Dikovska, Clara
Starchen Cove, Igor
Lorya, Dyna
Gailaite, Villa
Application Number:
JP2003579825A
Publication Date:
January 05, 2011
Filing Date:
April 03, 2003
Export Citation:
Assignee:
Topo Target UK Limited
International Classes:
C07D209/14; C07D295/16; A61K31/495; A61K31/496; A61K31/506; A61P17/06; A61P35/00; A61P43/00; C07D209/16; C07D209/18; C07D209/42; C07D213/36; C07D213/74; C07D239/42; C07D241/04; C07D295/18; C07D295/185; C07D295/192; C07D295/22; C07D295/26; C07D317/58; C07D333/60
Domestic Patent References:
| JP7278086A | ||||
| JP2001518081A | ||||
| JP2001523222A |
Foreign References:
| WO2000056704A1 | ||||
| WO2000069819A1 | ||||
| WO2003011851A1 | ||||
| WO2001044179A1 | ||||
| WO2000004892A1 | ||||
| WO2001085680A1 | ||||
| WO2001038322A1 | ||||
| WO2003007930A1 | ||||
| WO2003007954A1 | ||||
| US20020119962 | ||||
| US20020115863 |
Other References:
BARTA,T.E. et al,Synthesis and activity of selective MMP inhibitors with an aryl backbone,Bioorg Med Chem Lett,2000年,Vol.10, No.24,p.2815-7
JUNG,M. et al,Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation,J Med Chem,1999年,Vol.42, No.22,p.4669-79
JUNG,M. et al,Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation,J Med Chem,1999年,Vol.42, No.22,p.4669-79
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Yumi Naito
Ishii Teiji
Satoshi Fujita
Yumi Naito