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Document Type and Number:
Japanese Patent JP3037827
Kind Code:

PURPOSE: To obtain a new compound effective for various kinds of infectious diseases, having excellently antibacterial action on Escherichia coli, Pseudomonas aeruginosa, etc., and stability to decomposing enzymes such as DHP.
CONSTITUTION: A derivative of formula I [R1 is lower alkyl or (protected) hydroxyl lower alkyl; R2 is H or lower alkyl; R3 is carboxylprotecting group or H; R4 is H, lower alkyl, etc.; R5 is H, lower alkyl, etc.; R6 is H, hydroxyl, etc.; R7 and R8 are H, lower alkyl, etc.; Z is CH2, O, etc.; (m) and (n) are 0-4] and its salt such as (1R,5S,6S,8R,2'S,4'S)-2-((2-((1-(2aminoethanesulfony)piperazin-4- yl)carbonyl)pyroolidin-4-yl)thio)-6-(1-hydroxyethyl)-1-methylcarbapenem-4- carboxylic acid. The compound of formula I, for example, is obtained by reacting a compound of formula II with diphenylphosphoryl chloride to give a compound of formula III and reacting the compound of formula III with a thiol compound of formula IV.

Takashi Sasaki
Toshiyuki Nishi
Takeshi Hayano
Application Number:
Publication Date:
May 08, 2000
Filing Date:
June 15, 1992
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Daiichi Pharmaceutical Co., Ltd.
International Classes:
A61K31/495; A61K31/397; A61K31/496; A61P31/04; C07D477/00; (IPC1-7): C07D477/00
Attorney, Agent or Firm:
Miyuki Ariga (3 outside)