Title:
炭水化物複合生物活性化合物
Document Type and Number:
Japanese Patent JP3516959
Kind Code:
B2
Abstract:
Methods and compositions are provided which increase the cellular uptake of bioactive materials by covalently bonding such compounds to carbohydrate moieties through chemical linkers using other than glycosidic bonds. Numerous carbohydrates, linkers and bioactive materials can be joined in this way to form novel compositions, which are collectively referred to herein as glinkosides. Preferred glinkosides are preferentially taken up by glucose receptor and/or other cellular receptors, and once inside the cells, the glinkosides are cleaved into a sugar, a linker or linker fragments, and a biologically active compound. Various aspects of the invention include processes for synthesizing glinkosides, glinkoside compositions, and methods of treating diseases using glinkosides.
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Inventors:
ガニツク，エスミール
ザイフエルト，ビルフリート
ピエトルツコウスキー，ツビグニユー
ミルコビツチ，デユサン
ザイフエルト，ビルフリート
ピエトルツコウスキー，ツビグニユー
ミルコビツチ，デユサン
Application Number:
JP52371097A
Publication Date:
April 05, 2004
Filing Date:
December 12, 1996
Export Citation:
Assignee:
アイ・シー・エヌ・フアーマシユーテイカルズ
International Classes:
A61K31/70; A61K31/7028; A61K31/7042; A61K31/7052; A61K31/7056; A61K31/7064; C07H15/04; A61K31/7072; A61P25/00; A61P31/12; A61P35/00; A61P43/00; C07G3/00; C07H1/00; C07H9/04; C07H19/056; C07H19/06; C07H21/04; (IPC1-7): C07H19/06; A61K31/7056; A61P43/00; C07H15/04; C07H19/056; C07H21/04
Other References:
Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ，Ｖｏｌ．１１７（Ｎｏ．１）ｐ１６３〜１６８（１９９５）
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，Ｖｏｌ．３４，（Ｎｏ．６）Ｐ１８３０〜１８３７（１９９１）
Ｎａｔｕｒｅ，ｖｏｌ．３５５，Ｐ４６９〜４７２（１９９２）
Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ，ｖｏｌ．２８（Ｎｏ．３１）Ｐ３５８１〜３５８４（１９８７）
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，Ｖｏｌ．３４，（Ｎｏ．６）Ｐ１８３０〜１８３７（１９９１）
Ｎａｔｕｒｅ，ｖｏｌ．３５５，Ｐ４６９〜４７２（１９９２）
Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ，ｖｏｌ．２８（Ｎｏ．３１）Ｐ３５８１〜３５８４（１９８７）
Attorney, Agent or Firm:
川口 義雄 （外２名）