糖質コンジュゲートＲＮＡ剤およびその調製方法

Title:

糖質コンジュゲートＲＮＡ剤およびその調製方法

Document Type and Number:

Japanese Patent JP7071430

Kind Code:

B2

Abstract:

This disclosure relates to an improved process for the preparation of carbohydrate conjugates. The disclosure also relates to carbohydrate conjugated iRNA agents comprising these carbohydrate conjugates, which have improved purity and are advantageous for the in vivo delivery of the iRNA agents.

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Inventors:

Narayananan Naile Kay Jayapurakash
Alexander Vi Kellin
Pachamutu Kandasami
Rajiv Gee Karan Sottatil
Mutia Manoharan

Application Number:

JP2020066708A

Publication Date:

May 18, 2022

Filing Date:

April 02, 2020

Export Citation:

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Assignee:

Alniram Pharmaceuticals Incorporated

International Classes:

C07H21/02; C07H15/04

Domestic Patent References:

JP2011505425A

Other References:

HUANG, Xiaoguang et al.,The synthesis and biological evaluation of a novel series of C7 non-basic substituted fluoroquinolon,Bioorganic & Medicinal Chemistry Letters,2009年,vol.19, no.15,p.4130-4133,特に、p.4131左欄第24-27行、Scheme 2.

Attorney, Agent or Firm:

Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe

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