治療用途のための一酸化炭素放出分子ならびにその作製および使用の方法

Japanese Patent JP6670763

B2

Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.

One, Binhae
One, Danz
Ji, Shin Yu
Draganov, Alexander
Die, chaofeng
Damera, Krishna
Merlin, Didier
Benoas, Emily
Zen, Yuchin

JP2016571722A

March 25, 2020

June 09, 2015

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Georgia State University Research Foundation, Incorporated

A61K33/00; A61K31/045; A61K31/122; A61K31/5375; A61K31/7028; A61K31/7056; A61K47/54; A61K47/61; A61K47/64; A61K47/66; A61P1/04; A61P9/10; A61P17/02; A61P17/06; A61P19/02; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P43/00; C01B32/40; C07C13/26; C07C33/05; C07C49/657; C07C49/665; C07C49/747; C07C69/74; C07C69/757; C07C235/82

US5670664

Ukrainskii Khimicheskii,1981年,Vol.47,No.6,pp.646-649,[abstract]STN,CAPLUS,AN.1981:568840,DN.95:168840
Journal of Organic Chemistry,1999年,Vol.64,pp.680-681

Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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