Title:
カルボキサミド化合物およびそれらのヒト11CBY受容体アンタゴニストとしての使用
Document Type and Number:
Japanese Patent JP2004505070
Kind Code:
A
Abstract:
Compounds of formula (I) in which: each A is independently hydrogen, C1-6alkyl optionally substituted by hydroxyl, C1-6alkoxy, C1-6alkenyl or C1-6acyl group or a halogen atom or hydroxyl, CN or CF3 group; R3 is hydrogen, methyl or ethyl; R4 is an optionally substituted aromatic carbocyclic or heterocyclic ring; Z is an O or S atom, or an NH or CH2 group, or a single bond, at the 3 or 4 position of R4 relative to the carbonyl group; R5 is an optionally substituted aromatic carbocyclic or heterocyclic ring, or an optionally substituted, saturated or unsaturated, carbocyclic or heterocyclic ring; and Q is (a) Where X, Y, R1 and R2 are as defined in claim 1; are antagonists of a human 11CBy receptor.
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Inventors:
Johnson, christopher, norbert
Martin jones
Autur, Catherine, Anne
Jeff, Jeff
Seuris, kevin, michael
Whitty, David
Martin jones
Autur, Catherine, Anne
Jeff, Jeff
Seuris, kevin, michael
Whitty, David
Application Number:
JP2002515877A
Publication Date:
February 19, 2004
Filing Date:
July 26, 2001
Export Citation:
Assignee:
SmithKline Beecham p.l.c.
International Classes:
A61K31/165; A61K31/167; A61K31/275; A61K31/341; A61K31/343; A61K31/36; A61K31/381; A61K31/395; A61K31/40; A61K31/404; A61K31/415; A61K31/4155; A61K31/4164; A61K31/4245; A61K31/439; A61K31/44; A61K31/4402; A61K31/4436; A61K31/4439; A61K31/445; A61K31/4453; A61K31/4545; A61K31/472; A61K31/4965; A61K31/505; A61K31/5375; A61K31/55; A61K45/06; A61P1/04; A61P3/04; A61P3/10; A61P5/48; A61P7/10; A61P9/02; A61P9/04; A61P9/10; A61P9/12; A61P11/06; A61P15/00; A61P19/10; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P29/02; A61P31/00; A61P31/18; A61P35/00; A61P37/08; C07C233/75; C07C235/42; C07C235/48; C07C235/56; C07C235/84; C07C237/40; C07C255/57; C07C317/44; C07C323/62; C07D207/08; C07D209/08; C07D211/42; C07D213/56; C07D213/64; C07D213/82; C07D217/04; C07D223/04; C07D223/16; C07D231/12; C07D233/64; C07D239/46; C07D241/12; C07D271/06; C07D271/10; C07D277/04; C07D295/092; C07D295/08; C07D295/135; C07D295/155; C07D307/54; C07D307/79; C07D317/60; C07D333/24; C07D401/12; C07D409/04; C07D453/02; (IPC1-7): C07C233/75; A61K31/167; A61K31/275; A61K31/341; A61K31/343; A61K31/36; A61K31/381; A61K31/40; A61K31/404; A61K31/415; A61K31/4155; A61K31/4164; A61K31/4245; A61K31/439; A61K31/44; A61K31/4402; A61K31/4436; A61K31/4439; A61K31/445; A61K31/4453; A61K31/4545; A61K31/472; A61K31/4965; A61K31/505; A61K31/5375; A61K31/55; A61P1/04; A61P3/04; A61P3/10; A61P7/10; A61P9/02; A61P9/04; A61P9/10; A61P9/12; A61P11/06; A61P15/00; A61P19/10; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P29/02; A61P31/00; A61P31/18; A61P35/00; A61P37/08; C07C235/56; C07C235/84; C07C237/40; C07C317/44; C07C323/62; C07D207/08; C07D209/08; C07D211/42; C07D213/56; C07D213/64; C07D213/82; C07D217/04; C07D223/04; C07D223/16; C07D231/12; C07D233/64; C07D239/46; C07D241/12; C07D271/06; C07D271/10; C07D277/04; C07D295/08; C07D307/54; C07D307/79; C07D317/60; C07D333/24; C07D401/12; C07D409/04; C07D453/02
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Ishii Teiji
Satoshi Fujita
Ishii Teiji