ミクロソームトリグリセリド輸送タンパク質およびアポリポタンパク質分泌の阻害剤として有用なカルボキサミド

Title:

ミクロソームトリグリセリド輸送タンパク質およびアポリポタンパク質分泌の阻害剤として有用なカルボキサミド

Document Type and Number:

Japanese Patent JP3897594

Kind Code:

B2

Abstract:

Compounds of formula (I) wherein R2-C, R3-C, R4-C or R5-C may be replaced by N; and wherein n is 1, 2 or 3; R1 is aryl, heteroaryl or (aryl or heteroaryl)-lower alkoxy; R2, R3, R4 and R5 are independently hydrogen, lower alkyl, lower alkoxy, halo, trifluoromethyl or cyano; R6 is (i) or (ii) m is 1, 2 or 3; R7 is hydrogen, lower alkyl (aryl or heteroaryl)-lower alkyl, lower alkoxy, (aryl or heteroaryl)-lower alkoxy, hydroxy, oxo, lower alkylenedioxy or lower alkanoyloxy; W is O, S or NR8; R8 is -CORa, (iii), -COORd, -SO2Re, hydrogen, optionally substituted lower alkyl, aryl, heteroaryl or (aryl or heteroaryl)-lower alkyl; Ra, Rd and Re are independently optionally substituted lower alkyl, cycloalkyl, adamantyl, aryl, heteroaryl or (aryl or heteroaryl)-lower alkyl; Rb and Rc are independently hydrogen, cycloalkyl, optionally substituted lower alkyl, aryl, heteroaryl or (aryl or heteroaryl) lower alkyl; or Rb and Rc together represent lower alkylene; and pharmaceutically acceptable salts thereof; and enantiomers thereof; which are useful as inhibitors of microsomal triglyceride transfer protein (MTP) and of apolipoprotein B (apoB) secretion.

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Inventors:

Gary Michael Xander

Application Number:

JP2001553264A

Publication Date:

March 28, 2007

Filing Date:

January 16, 2001

Export Citation:

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Assignee:

NOVARTIS AG

International Classes:

C07D211/46; A61K31/4355; C07D295/12; A61K31/445; A61K31/495; A61K31/496; A61K31/535; A61P3/06; A61P9/10; C07D211/62; C07D213/36; C07D213/38; C07D213/74; C07D213/81; C07D213/82; C07D295/135; C07D295/18; C07D295/185; C07D295/192; C07D295/20; C07D295/205; C07D295/215; C07D295/22; C07D295/26; C07D491/10; C07D491/113

Domestic Patent References:

JP8109130A
JP8503228A
JP2000505810A

Foreign References:

WO2000032582A1
WO2000005201A1

Attorney, Agent or Firm:

Aoyama Aoi
Kazuaki Kojima
Mitsutaka Iwasaki

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