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Title:
CARBOXYLIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH02275846
Kind Code:
A
Abstract:

NEW MATERIAL: A carboxylic acid derivative of formula I (wherein Ar1 is unsubstituted or substituted aryl; Ar2 is unsubstituted or substituted arylene; R1 is H, an aliphatic group or an aryl-aliphatic group; R2 is an aliphatic group or an aryl-aliphatic group; R3 is H, lower alkyl or lower alkanoyl; and Z is a divalent aliphatic group) and a salt thereof.

EXAMPLE: {0-[(2,6-Dichlorophenyl)amino]phenyl}aceto-N-methylhydroxamic acid.

USE: Useful as pharmaceuticals, for example for anti-inflammatory or anti-allergic.

PREPARATION: A compound of formula II is reacted with a compound of formula III, or the protecting group P1 in the compound of formula IV or a salt thereof is converted into hydrogen, or a compound of formula V is reacted with a compound of formula VI (wherein X1 is reactive esterified hydroxy) to obtain a compound of formula I.


Inventors:
ARUFUREETO ZARUMAN
Application Number:
JP33886089A
Publication Date:
November 09, 1990
Filing Date:
December 28, 1989
Export Citation:
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Assignee:
CIBA GEIGY AG
International Classes:
A61K31/16; A61P37/08; A61P43/00; C07C259/06; (IPC1-7): A61K31/16; C07C259/06
Attorney, Agent or Firm:
Aoki Akira (3 outside)