Title:
CARBOXYLIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH1067743
Kind Code:
A
Abstract:
To obtain a novel compound which is useful as a synthetic intermediate for a dihydropyridine derivative used in treatment of circulatory disorder and cardiovascular functional disorder.
This compound is represented by formula I [R4 is a (substituted) 1-12C alkyl, an alkenyl; Y is formula II (B is-NH; R13 is a 1-12C alkyl; R14 is H, a 1-12C alkyl; A is H, methyl);D is O, -NH; E is two H, =CHR1 (R1 is a 1-6C alkyl)], typically (1R,2S)-[ 1-methyl-2-methoxycarbonyl-2-(4-tolylsulfamoyl)] ethyl 1,4-dihydro-2,6-dimetyl-3-nitro-4-phenylpyridine-5-carboxylate. The compound of formula I is prepared by reaction of a compound of the formula: HO-Y with diketene of formula III.
Inventors:
STOLTEFUSS JUERGEN
BECHEM MARTIN
GROSS RAINER
HEBISCH SIEGBERT
SCHRAMM MATTHIAS
BECHEM MARTIN
GROSS RAINER
HEBISCH SIEGBERT
SCHRAMM MATTHIAS
Application Number:
JP22421497A
Publication Date:
March 10, 1998
Filing Date:
August 06, 1997
Export Citation:
Assignee:
BAYER AG
International Classes:
A61K31/435; A61K31/44; A61K31/443; A61K31/445; A61K31/451; A61P9/00; A61P9/08; A61P9/10; C07C229/00; C07C229/22; C07C233/47; C07C233/83; C07C251/08; C07C271/00; C07C271/22; C07C275/00; C07C275/28; C07C311/00; C07C311/19; C07C333/00; C07C335/00; C07D211/90; C07D211/98; C07D405/06; C07D417/12; C07D491/04; C07D491/048; C07F9/59; (IPC1-7): C07D211/90; A61K31/435; A61K31/445; C07D405/06; C07D417/12; C07F9/59
Attorney, Agent or Firm:
Heiyoshi Odashima