Title:
【発明の名称】ヒトBCDFを含有するパーキンソン病治療支持剤
Document Type and Number:
Japanese Patent JP3143916
Kind Code:
B2
Abstract:
PURPOSE:To provide a Parkinson disease treatment-supporting agent effectively treating Parkinson disease by compounding a human B cell differentiation factor as an active ingredient. CONSTITUTION:0.0001-100wt.%, preferably 0.1-1.0wt.%, of a human B cell differentiation factor (BCDF) having an amino acid sequence of the formula, a human Ala-BCDF prepared by adding an Ala molecule to the N terminal thereof, a derivative prepared by adding one or more amino acid molecules to the N terminal and/of C terminal of the human BCDF, a derivative prepared by substituting one or more amino acid groups of the human BCDF with other amino acids or a compound having the human BCDF activity is compounded, if necessary, with other a stabilizer such as serum albumin and an excipient such as an artificial cerebrospinal liquid or mannitol and to provide the objective agent. The agent can directly be administered into a cerebral tissue or cerebral ventricle with a penetration pump, etc.
Inventors:
Hitoshi Nishino
Takeshi Hataya
Kunio Torii
Yukio Akiyama
Takeshi Hataya
Kunio Torii
Yukio Akiyama
Application Number:
JP26745290A
Publication Date:
March 07, 2001
Filing Date:
October 04, 1990
Export Citation:
Assignee:
AJINOMOTO CO.,LTD.
International Classes:
A61K38/00; A61P25/00; A61P25/16; (IPC1-7): A61K38/00; A61P25/16
Domestic Patent References:
| JP1106827A | ||||
| JP6226229A |
Other References:
ＢＪＯＲＫＬＵＮＤ，Ａ．，ｅｔ ａｌ．，Ｂｒａｉｎ Ｒｅｓｅａｒｃｈ，１７７，１９７９，ｐｐ．５５５−５６０