Title:
複素環式の酸化窒素供与体基を含む心血管化合物、組成物および使用方法
Document Type and Number:
Japanese Patent JP2008528507
Kind Code:
A
Abstract:
The invention describes compositions and kits comprising at least one cardiovascular compound comprising at least one heterocyclic nitric oxide donor group, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (l) treating peripheral vascular diseases; (m) treating portal hypertension and (n) treating ophthalmic disorders. The cardiovascular compounds are preferably beta-adrenergic antagonists, angiotensin-converting enzyme (ACE) inhibitors, anti-hyperlipidemic compounds, and antithrombotic and vasodilator compounds. The heterocyclic nitric oxide donor groups are preferably furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines.
Inventors:
Garvey David S.
Application Number:
JP2007552318A
Publication Date:
July 31, 2008
Filing Date:
January 23, 2006
Export Citation:
Assignee:
Nitromed Incorporated
International Classes:
C07D271/04; A61K31/41; A61K31/4245; A61K31/427; A61K31/4725; A61K31/5377; A61K31/55; A61K31/551; A61K31/554; A61K45/00; A61P1/16; A61P3/06; A61P3/10; A61P5/18; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P15/00; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P31/04; A61P35/00; A61P39/00; A61P39/06; A61P41/00; A61P43/00; C07D271/08; C07D273/00; C07D413/12; C07D413/14; C07D417/04; C07D417/14; C07D487/04
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi