Title:
無担体生物活性タンパク質ナノ構造体
Document Type and Number:
Japanese Patent JP7097667
Kind Code:
B2
Abstract:
The present disclosure provides compositions and methods for efficient and effective protein delivery in vitro and in vivo. In some aspects, proteins are reversibly crosslinked to each other and/or modified with functional groups and protected from protease degradation by a polymer-based or silica-based nanoshell.
Inventors:
Lee Tan
Darrell Jay Irvine
Darrell Jay Irvine
Application Number:
JP2016517553A
Publication Date:
July 08, 2022
Filing Date:
September 26, 2014
Export Citation:
Assignee:
Massachusetts Institute of Technology
International Classes:
A61K47/50; A61K9/16; A61K35/17; A61K38/00; A61K38/22; A61K39/00; A61K39/395; A61P3/10; A61P9/00; A61P35/00; A61P37/06
Domestic Patent References:
| JP2013511539A | ||||
| JP2007131568A | ||||
| JP2009542592A | ||||
| JP2007528726A |
Other References:
Polymer Chemistry(PAPER),2013,Vol.4,No.8,p.2464-2469
Soft Matter,2012,Vol.8,p.2644-2650
BIOCONJUGATE CHEMISTRY,2012,Vol.23,No.7,p.1452-1462
Biochemical and Biophysical Research Communications,2008,Vol.367,p.330-335
最新医学,2009,Vol.64,No.11,p.58-64
NATURE MEDICINE,2010,Vol.16,No.9,p.1035-1041
Soft Matter,2012,Vol.8,p.2644-2650
BIOCONJUGATE CHEMISTRY,2012,Vol.23,No.7,p.1452-1462
Biochemical and Biophysical Research Communications,2008,Vol.367,p.330-335
最新医学,2009,Vol.64,No.11,p.58-64
NATURE MEDICINE,2010,Vol.16,No.9,p.1035-1041
Attorney, Agent or Firm:
Takuji Yamada
Yasushi Ochiai
Yasushi Ochiai