COMPOSITION FOR INHIBITION OF CATHEPSIN K

Title:

COMPOSITION FOR INHIBITION OF CATHEPSIN K

Document Type and Number:

Japanese Patent JP2017095512

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide compositions for the treatment of disorders associated with abnormal bone resorption which have therapeutic advantage, convenience, patient compliance and patient satisfaction greater than those of other therapies.SOLUTION: The present invention provides: a cathepsin K inhibitor involved in osteoclast-mediated bone resorption; and a method of inhibiting bone resorption of a mammal in need treatment using an oral pharmaceutical composition containing a cathepsin K inhibitor represented by the formula (I) or a pharmaceutically acceptable salt thereof or a mixture thereof according to a continuous schedule having a dosage interval of once weekly, biweekly, twice monthly or once monthly.SELECTED DRAWING: None

Inventors:

DAIFOTIS ANASTASIA
STOCH SELWYN AUBREY
INCE BASIL AVERY
BLACK CAMERON

Application Number:

JP2017013864A

Publication Date:

June 01, 2017

Filing Date:

January 30, 2017

Export Citation:

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Assignee:

MERCK SHARP & DOHME
MERCK CANADA INC

International Classes:

A61K31/275; A61K9/08; A61K9/14; A61K9/20; A61K9/48; A61K31/045; A61K47/12; A61K47/26; A61K47/38; A61P19/08; A61P19/10; A61P43/00

Domestic Patent References:

JP2004256525A

2004-09-16

Foreign References:

WO2003075836A2	2003-09-18
WO2003039534A1	2003-05-15
WO1998001133A1	1998-01-15
WO2003051373A1	2003-06-26

Other References:

J. CELL. BIOCHEM., 2003, VOL.88, PP.259-266, JPN6011054462
AM. J. CLIN. NUTR., 2003, VOL.77, PP.204-210, JPN6011054464

Attorney, Agent or Firm:

Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama

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