Title:
CCR5 ANTAGONIST USEFUL FOR TREATMENT OF AIDS
Document Type and Number:
Japanese Patent JP2008074862
Kind Code:
A
Abstract:
To provide CCR5 antagonists.
Disclosed are compounds of formula I (wherein Q, X, and Z are each CH or N; and R and R1 to R8 are each a specified substituent) and compositions containing them. These compounds are effective for the treatment of HIV AIDS, solid organ transplantation rejection, graft versus host diseases, inflammatory diseases, atopic dermatitis, asthma, allergies, or multiple sclerosis.
Inventors:
MILLER MICHAEL W
Application Number:
JP2007279663A
Publication Date:
April 03, 2008
Filing Date:
October 26, 2007
Export Citation:
Assignee:
SCHERING CORP
International Classes:
C07D401/14; A61K31/18; A61K31/506; A61P1/04; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D403/06; C07D409/14; C07D417/14
Domestic Patent References:
| JP2004545157A | ||||
| JP4248251B2 | 2009-04-02 |
Foreign References:
| WO2000066558A1 | 2000-11-09 | |||
| WO2000066559A1 | 2000-11-09 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita