CD40 ANTIBODY FORMULATION AND METHOD

Title:

CD40 ANTIBODY FORMULATION AND METHOD

Document Type and Number:

Japanese Patent JP2011184446

Kind Code:

A

Abstract:

To provide a method of treating a tumor in a patient and a stable liquid pharmaceutical formulation suitable for parenteral administration comprising administering a CD40 agonist antibody to the patient.

The invention relates to treatment comprising administering to a patient a CD40 agonist antibody or a fragment thereof, wherein the antibody is administered according to an intermittent dosing regimen of at least two cycles, each cycle comprising (a) a dosing period during which a therapeutically effective amount of the CD40 agonist antibody is administered to the patient and thereafter (b) a resting period. In one embodiment, the administration produces a plasma concentration of the antibody of 0.01-10 μg/mL for at least three hours and the resting period is for at least one week. The formulation comprises an anti-CD40 antibody, sodium acetate, sodium chloride, and polysorbate 80.

Inventors:

BEDIAN VAHE
CUSMANO JOHN DANIEL
GLADUE RONALD PAUL

Application Number:

JP2011100868A

Publication Date:

September 22, 2011

Filing Date:

April 28, 2011

Export Citation:

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Assignee:

PFIZER PROD INC

International Classes:

A61K39/395; A61K9/08; A61K47/02; A61K47/12; A61K47/14; A61P35/00; C07K16/28; C07K16/18

Domestic Patent References:

JPH03204821A	1991-09-06
JPS63192724A	1988-08-10
JP2002504907A	2002-02-12

Foreign References:

WO2003040170A2	2003-05-15
WO2003039485A2	2003-05-15
WO2003009817A2	2003-02-06
WO2001048554A1	2001-07-05
WO2002030463A2	2002-04-18
WO2001047554A1	2001-07-05

Attorney, Agent or Firm:

Yoshinobu Murofushi
High Hoji Koji
Junko Miyazawa
Noh four
Maki Sato

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