Title:
CELLS HAVING DISRUPTED EXPRESSION OF PROTEINS INVOLVED IN ADME AND TOXICOLOGY PROCESSES
Document Type and Number:
Japanese Patent JP2018078905
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide cells comprising disrupted expression of at least one membrane transporter, drug metabolizing enzyme, xenobiotic sensor, or cellular stress response pathway protein.SOLUTION: A human cell line comprises disrupted expression of at least one protein involved in a drug absorption, distribution, metabolism, and excretion and/or toxicology process, and the protein is selected from membrane transporter, drug metabolizing enzyme, xenobiotic sensor, cellular stress response pathway protein and combinations of them.SELECTED DRAWING: None
Inventors:
MAUREEN BOURNER
TIMOTHY BRAYMAN
GARY DAVIS
MICHAEL D MITCHELL
DAVID C THOMPSON
YONGLING XIAO
TIMOTHY BRAYMAN
GARY DAVIS
MICHAEL D MITCHELL
DAVID C THOMPSON
YONGLING XIAO
Application Number:
JP2018005634A
Publication Date:
May 24, 2018
Filing Date:
January 17, 2018
Export Citation:
Assignee:
SIGMA ALDRICH CO LLC
International Classes:
C12N5/10; C12Q1/06; G01N33/15; G01N33/50; G01N33/68
Domestic Patent References:
| JP2003532390A | 2003-11-05 |
Other References:
DRUG METAB. PHARMACOKINET., vol. Vol. 22, No. 4, JPN6018047560, 2007, pages p. 276-286
NATURE BIOTECHNOLOGY, vol. 27, no. 9, JPN6016008721, 2009, pages 851 - 857
GENES TO CELLS, vol. Vol.15, JPN6016008722, August 2010 (2010-08-01), pages 875 - 885
NATURE BIOTECHNOLOGY, vol. 27, no. 9, JPN6016008721, 2009, pages 851 - 857
GENES TO CELLS, vol. Vol.15, JPN6016008722, August 2010 (2010-08-01), pages 875 - 885
Attorney, Agent or Firm:
Kenji Sugimura
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