NEW MATERIAL:A compound(salt) shown by the formula I [R1 is α-aminoacyl, dipeptidyl consisting of an α-amino acid, etc.; R2 is group shown by the formula II(R5 and R6 are H, lower alkyl, or R5 and R6 are linked to form a ring consisting of methylene chain; X is H, lower alkyl, carboxy, etc.); R3 is H, methyl, chlorine, methoxy, etc.; R4 is H, or ester residue].
EXAMPLE: 7-[(Z)-2-(2-L-Alanylamino-4-thiazolyl)-2-methoxyimino-acetamido]-3-methyl-3-caphem-4-carboxylic acid.
USE: A preventive and remedy for microbism.
PROCESS: For example, the amino group of a compound shown by the formula III(R7 is ester residue) is protected and hydrolyzed to give a carboxylic acid derivative, which is reacted with a 7-amino-cephalosporin shown by the formula IVto give a reaction product whose amino-protecting group is removed to give a compound shown by the formula I .
NAKAGAWA SUSUMU
IWATSUKI IKUO
IWADARE SHIYUUICHI
