Title:
Change of the recombination adenovirus by an immunogenicity malaria parasite circumference sporozoite protein epitope
Document Type and Number:
Japanese Patent JP5947719
Kind Code:
B2
Abstract:
The present disclosure relates to adenovirus protein modifications to augment immune response to a transgene of a recombinant adenovirus and to circumvent pre-existing anti-adenovirus immunity. Some embodiments are directed to a recombinant adenovirus derived from a recombinant adenovirus plasmid vector, wherein the recombinant adenovirus plasmid vector comprises a nucleotide sequence encoding a Plasmodium circumsporozoite protein, or antigenic portion thereof, operably linked to a heterologous promoter and a modified capsid or core protein, wherein an immunogenic epitope of Plasmodium circumsporozoite is inserted into or replaces at least part of a capsid or core protein. Other embodiments are directed to a pharmaceutical composition or a malaria vaccine composition comprising a recombinant adenovirus according to the above embodiments. Further embodiments include a method of treating, preventing, or diagnosing malaria, comprising administering a therapeutic amount of the pharmaceutical composition or malaria vaccine composition in accordance with the above embodiment.
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Inventors:
Noriyuki Shirato
Moriya Tsuji
Moriya Tsuji
Application Number:
JP2012525677A
Publication Date:
July 06, 2016
Filing Date:
August 18, 2010
Export Citation:
Assignee:
The Rockefeller University
International Classes:
C12N7/01; A61K39/015; A61K39/235; A61P33/06; C12N15/09
Domestic Patent References:
| JP2005500336A | ||||
| JP2005287309A |
Foreign References:
| WO2008140474A1 | ||||
| US6066623 | ||||
| WO2004101799A1 |
Other References:
BOWMAN S et al., Database GenBank[online], Accession No.Q7K740, , 12-JAN-2007 uploaded, 26-NOV-2014 retrieved, Definition: Circumsporozoite (CS) protein.
J. Immunol., 1995, Vol.154, p.2784-2793
J. Immunol., 1995, Vol.154, p.2784-2793
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office