Title:
シャペロニン10のアンタゴニスト
Document Type and Number:
Japanese Patent JP3987104
Kind Code:
B2
Abstract:
Antibodies raised against recombinant or synthetic cpn10 are disclosed. The cpn10 has the sequence GSMAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQ ATVEAVGSGSKGKGGEIQPVSVKEGDKVLLPEYGGTKVVLDDKDYFLFRDGDIL GKYVD (SEQ ID NO: 21 ). Antibodies are raised against either the entire sequence of cpn 10, or a shorter peptide sequence derived from cpn 10, such as Ac-AGQAFRKFLPL (SEQ ID NO: 2 ), ACQAFRKFLPL (SEQ ID NO 1 ), or EKSQGKVLQAT (SEQ ID NO: 3 ), in which the peptides may have a single amino acid deletion, addition or substitution. The antibodies can be used to terminate pregnancy, suppress tumor cell growth or enhance the immune system.
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Inventors:
Morton, Halle
Cabanafu, Alice Christina
Cabanafu, Alice Christina
Application Number:
JP51529695A
Publication Date:
October 03, 2007
Filing Date:
November 30, 1994
Export Citation:
Assignee:
Rohm and Haas Electronic Materials LLC
International Classes:
C12P21/08; A61K38/00; G01N33/53; A61K39/395; A61K45/00; A61P5/00; A61P15/06; A61P15/08; A61P17/00; A61P17/02; A61P25/20; A61P29/00; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P37/06; A61P37/08; C07K7/06; C07K14/00; C07K14/47; C07K16/18; C12N15/09; C12P21/02; C12R1/19
Domestic Patent References:
| JP2501160A |
Foreign References:
| WO1986005498A1 | ||||
| WO1988004779A1 |
Other References:
Biochim.Biophys.Acta.,Vol.1164,No.2(1993)p.219-222
Proc.Natl.Acad.Sci.USA.,Vol.89,No.8(1992)p.3394-3398
J.Leukoc.Biol.,Vol.0,No.Suppl.(1993)p.48
Cancer Immunol.Immunother.,Vol.34,No.4(1992)p.265-271
J.Reprod.Fertil.,Vol.92,No.2(1991)p.443-451
Clin.Exp.Immunol.,Vol.80,No.1(1990)p.100-108
Proc.Natl.Acad.Sci.USA.,Vol.89,No.8(1992)p.3394-3398
J.Leukoc.Biol.,Vol.0,No.Suppl.(1993)p.48
Cancer Immunol.Immunother.,Vol.34,No.4(1992)p.265-271
J.Reprod.Fertil.,Vol.92,No.2(1991)p.443-451
Clin.Exp.Immunol.,Vol.80,No.1(1990)p.100-108
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Kyousei Tamura