Title:
CHIMERIC ANTIGEN RECEPTOR EFFECTOR CELL SWITCHES WITH HUMANIZED TARGETING MOIETIES AND/OR OPTIMIZED CHIMERIC ANTIGEN RECEPTOR INTERACTING DOMAINS, AND USES THEREOF
Document Type and Number:
Japanese Patent JP2022185016
Kind Code:
A
Abstract:
To provide a safer and more versatile immunotherapy.SOLUTION: The present disclosure provides compositions, methods, kits and platforms for selectively activating and deactivating chimeric receptor effector cells using humanized chimeric receptor effector cell switches that comprise a humanized targeting moiety that binds to CD19 on a target cell and a chimeric receptor interacting domain that binds to a chimeric receptor effector cell and/or chimeric receptor effector cell switches comprising optimized chimeric receptor interacting domains. Also disclosed are methods of treating diseases and conditions with such chimeric receptor effector cells and chimeric receptor effector cell switches.SELECTED DRAWING: Figure 30
Inventors:
TRAVIS S YOUNG
LEONARD PRESTA
DAVID RODGERS
ERIC HAMPTON
TIMOTHY WRIGHT
PETER G SCHULTZ
EDUARDO LABORDA
ELVIRA KHIALEEVA
SOPHIE VIAUD
LEONARD PRESTA
DAVID RODGERS
ERIC HAMPTON
TIMOTHY WRIGHT
PETER G SCHULTZ
EDUARDO LABORDA
ELVIRA KHIALEEVA
SOPHIE VIAUD
Application Number:
JP2022153946A
Publication Date:
December 13, 2022
Filing Date:
September 27, 2022
Export Citation:
Assignee:
SCRIPPS RESEARCH INST
International Classes:
C12N15/62; A61K38/16; A61P35/00; A61P35/02; A61P43/00; C07K14/705; C07K16/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/0783; C12N5/10; C12N15/12; C12N15/13; C12N15/63
Attorney, Agent or Firm:
Makoto Ono
Kanayama Sage
Yoshiyuki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Yoshie Sakurada
Yosuke Kawasaki
Youichi Iino
Yusuke Ichikawa
Takashi Kono
Yoshikazu Iwase
Yasufumi Shiroyama
Kanayama Sage
Yoshiyuki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Yoshie Sakurada
Yosuke Kawasaki
Youichi Iino
Yusuke Ichikawa
Takashi Kono
Yoshikazu Iwase
Yasufumi Shiroyama