Title:
Ｂ細胞成熟抗原を標的指向するキメラ抗原受容体
Document Type and Number:
Japanese Patent JP6989634
Kind Code:
B2
Abstract:
The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
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Inventors:
Cofender Fur, James Noble
Application Number:
JP2020018005A
Publication Date:
January 05, 2022
Filing Date:
February 05, 2020
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
C12N15/62; A61K31/7088; A61K35/17; A61K35/76; A61K47/68; A61P35/00; A61P43/00; C07K16/28; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/63
Foreign References:
| WO2011041093A1 | ||||
| WO2010104949A2 |
Other References:
J. Immunother.,2009年,Vol.32, No.7,p.689-702(p.1-26)
Attorney, Agent or Firm:
Takashima Ichi
Mitsunori Kamata
Kyoko Doi
Yaeko Tamura
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki
Yosuke Ito
Takayuki Ohara
Mitsunori Kamata
Kyoko Doi
Yaeko Tamura
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki
Yosuke Ito
Takayuki Ohara