Title:
CHIMERIC IMMUNORECEPTOR USEFUL IN TREATING HUMAN CANCER
Document Type and Number:
Japanese Patent JP2010047591
Kind Code:
A
Abstract:
To provide chimeric transmembrane immunoreceptors, named "zetakines", comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a transmembrane region and an intracellular signaling domain.
The glioma-specific immunoreceptor comprises the extracellular targeting domain of the IL-13R2-specific IL-13 mutant IL-13(E13Y) linked to the Fc region of IgG, the transmembrane domain of human CD4, and the human CD3 zeta chain.
Inventors:
JENSEN MICHAEL
Application Number:
JP2009238358A
Publication Date:
March 04, 2010
Filing Date:
October 15, 2009
Export Citation:
Assignee:
HOPE CITY
International Classes:
C07K14/705; C12N15/09; A61K35/26; A61K39/395; A61P35/00; C07K14/715; C07K19/00; C12N5/08; A61K38/00; A61K39/00
Foreign References:
| WO2000023573A2 | 2000-04-27 |
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa
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