Title:
キメラタンパク質
Document Type and Number:
Japanese Patent JP6836508
Kind Code:
B2
Abstract:
The present invention provides a chimeric protein having the formula: Casp-Ht1-Ht2whereinCasp is a caspase domain;Ht1 is a first heterodimerization domain; andHt2 is a second heterodimerization domainand wherein, in the presence of a chemical inducer of dimerization (CID), an identical pair of the chimeric proteins interact such that Ht1 from one chimeric protein heterodimerizes with Ht2 from the other chimeric protein, causing homodimerization of the two caspase domains. The invention also provides a cell comprising such a protein and its use in adoptive cell therapy.
Inventors:
Pule, martin
Trowbridge, Ryan
Edward Hodgkin
Trowbridge, Ryan
Edward Hodgkin
Application Number:
JP2017542093A
Publication Date:
March 03, 2021
Filing Date:
February 23, 2016
Export Citation:
Assignee:
UCL Business Limited
International Classes:
C12N15/09; A61K31/436; A61K35/17; A61K35/28; A61K48/00; A61P35/00; A61P43/00; C07K14/435; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/16
Domestic Patent References:
| JP2002514893A |
Foreign References:
| WO2014197638A1 | ||||
| US20040040047 |
Other References:
N Engl J Med.,2011年,365(18),p.1673-1683
Chem. Rev.,2010年,110(6),p.3315-3336
Chem. Rev.,2010年,110(6),p.3315-3336
Attorney, Agent or Firm:
Takeshi Oshio