Title:
クロメノンモノカルボン酸トランスポータ阻害薬
Document Type and Number:
Japanese Patent JP6713472
Kind Code:
B2
Abstract:
The invention provides compounds effective as inhibitors of monocarboxylate transporters such as MCT1 and MCT4, which can be used for treatment of medical conditions wherein treatment of the condition with a compound having an inhibitor effect on MCT1, MCT4, or both is medically indicated. Compounds of the invention can have antitumor, antidiabetes, anti-inflammatory, or immunosuppressive pharmacological effects, and can be effective for treatment of cancer and of type II diabetes.
Inventors:
Bannister, Thomas Dee
Won, Phi
Wong, Chao
Cleveland, John El
Won, Phi
Wong, Chao
Cleveland, John El
Application Number:
JP2017538317A
Publication Date:
June 24, 2020
Filing Date:
January 22, 2016
Export Citation:
Assignee:
The Script Research Institute
International Classes:
C07D311/22; A61K31/155; A61K31/352; A61K31/427; A61K31/453; A61K31/4709; A61K31/4725; A61K31/506; A61P3/10; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07D311/30; C07D405/12; C07D417/12
Foreign References:
| WO2014195507A1 |
Other References:
SABINA PASSAMONTI,BIOAVAILABILITY OF FLAVONOIDS: A REVIEW OF THEIR MEMBRANE TRANSPORT AND THE FUNCTION OF BILITRANSLOCASE IN ANIMAL AND PLANT ORGANISMS,CURRENT DRUG METABOLISM,2009年,VOL:10,PAGE(S):369 - 394,URL,https://www.researchgate.net/publication/26285456_Bioavailability_of_Flavonoids_A_Review_of_Their_Membrane_Transport_and_the_Function_of_Bilitranslocase_in_Animal_and_Plant_Organisms
HUI WANG,SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF PTERIDINE DIONE AND TRIONE MONOCARBOXYLATE TRANSPORTER 1 INHIBITORS,JOURNAL OF MEDICINAL CHEMISTRY,2014年,VOL:57,PAGE(S):7317 - 7324,URL,http://dx.doi.org/10.1021/jm500640x
HUI WANG,SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF PTERIDINE DIONE AND TRIONE MONOCARBOXYLATE TRANSPORTER 1 INHIBITORS,JOURNAL OF MEDICINAL CHEMISTRY,2014年,VOL:57,PAGE(S):7317 - 7324,URL,http://dx.doi.org/10.1021/jm500640x
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoichi Iino
Yusuke Ichikawa
Masahiro Moriyama
Yoshikazu Iwase
Yasufumi Shiroyama