Title:
CLATHRATE COMPOUND OF IBUPROXAME AND BETA- CYCLODEXTRIN, MANUFACTURE AND MEDICINE
Document Type and Number:
Japanese Patent JPS63183546
Kind Code:
A
Abstract:
A new inclusion complex of ibuproxam with beta-cyclodextrin is described, which is prepared by adding ibuproxam to a boiling aqueous solution of beta-cyclodextrin, stirring the reaction mixture at the boiling temperature, cooling to a temperature of 0 DEG to 5 DEG C and isolating the title complex. The analgesic, antipyretic and antiinflammatory propeties of the inclusion complex of ibuproxam with beta-cyclodextrin are equivalent to those of ibuproxam alone, but owing to its better water-solubility the complex can be more easily formulated into pharmaceutical forms.
Inventors:
YANKO TSUMITETSUKU
JIENII MIROBUATSUKU
TSUDORABUKO KOPITARU
MIRUYAMU TSUORUTSU
PORISU RUSUYAKOBUSUKII
JIENII MIROBUATSUKU
TSUDORABUKO KOPITARU
MIRUYAMU TSUORUTSU
PORISU RUSUYAKOBUSUKII
Application Number:
JP28568387A
Publication Date:
July 28, 1988
Filing Date:
November 13, 1987
Export Citation:
Assignee:
LEK TOVARNA FARMACEVTSKIH
International Classes:
C08B37/16; A61K31/165; A61K47/00; A61K47/48; A61P25/04; A61P29/00; C07C67/00; C07C239/00; C07C259/06; C08B37/00; (IPC1-7): A61K31/165; A61K47/00; C07C83/10; C08B37/16
Attorney, Agent or Firm:
Shigeru Yagita (2 outside)
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