Title:
CLAVULANIC ACID DERIVATIVE* ITS MANUFACTURE AND USE
Document Type and Number:
Japanese Patent JPS5649386
Kind Code:
A
Abstract:
The compounds of the formula (II): (II) or pharmaceutically acceptable salts or esters thereof wherein A is a hydrogen atom or an esterifying radical; X is an alkyl group of 1-12 carbon atoms optionally substituted by a hydroxy, amino, acylamino of C1-6 alkoxy group, which substituents are not on the carbon atom adjacent to the nitrogen atom; or a C5-7 cycloalkyl group; or a phenylalkyl group wherein the carbon atom content of the alkyl part is 1-6 and the phenyl part is optionally substituted with a fluorine, bromine, chlorine, C1-6 alkyl, or C1-6 alkoxy; with the proviso that when X represents an optionally substituted phenylalkyl group and A represents C1-3 alkyl, then the -CO2A group is attached to the alkyl part of the phenylalkyl group; have been found to be beta -lactamase inhibitors and antibacterial agents. Their preparation and use is described.
Inventors:
JIYON BARI HAABURITSUJI
AIRIIN SUTAARINGU
BURAIAN PIITAA KURAAKU
AIRIIN SUTAARINGU
BURAIAN PIITAA KURAAKU
Application Number:
JP10761380A
Publication Date:
May 02, 1981
Filing Date:
August 04, 1980
Export Citation:
Assignee:
BEECHAM GROUP LTD
International Classes:
A61K31/42; C07C229/38; C07C271/22; C07D498/04; C07D503/00; (IPC1-7): A61K31/42; C07D498/04
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