Title:
レヴィー小体病におけるαシヌクレインの切断断片
Document Type and Number:
Japanese Patent JP5766923
Kind Code:
B2
Abstract:
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in trycine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue (117) and before residue (126) of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.
Inventors:
Tammy Jay Chill Cote
Jason Gold Stain
John P. Anderson
Weaping Guy
Jason Gold Stain
John P. Anderson
Weaping Guy
Application Number:
JP2010203787A
Publication Date:
August 19, 2015
Filing Date:
September 10, 2010
Export Citation:
Assignee:
Elan Pharmaceuticals, Limited Liability Company
The Trustees of Flinders University
The Trustees of Flinders University
International Classes:
G01N33/53; A01K67/00; A01K67/027; A01K67/033; A01N43/04; A61K31/70; A61K39/395; C07K1/00; C07K14/00; C07K14/47; C07K16/18; C07K17/00; C12N15/09; C12N15/10; C12Q1/02; C12Q1/37; C12Q1/68; G01N33/00; G01N33/15; G01N33/50; G01N33/68; A61K
Foreign References:
| WO1999050300A1 |
Other References:
CROWTHER,R.A. et al.,Synthetic filaments assembled from C-terminally truncated alpha-synuclein.,FEBS Lett.,1998年10月 9日,vol.436, No.3,p.309-12
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita