Title:
ゴナドトロピン放出ホルモン受容体のクローニングおよび発現
Document Type and Number:
Japanese Patent JP3719712
Kind Code:
B2
Abstract:
The present invention relates to the GnRH-R genes and proteins. The DNA sequences disclosed herein may be engineered into expression systems designed for the production of GnRH-R and/or cell lines which express the GnRH-R and preferably respond to GnRH induced signal transduction. Such cell lines may advantageously be used for screening and identifying GnRH agonists and antagonists. In accordance with another aspect of the invention, the GnRH DNA, antisense oligonucleotide sequences, the GnRH expression products, and antibodies to such products may be used in the diagnosis and therapy of reproductive disorders associated with abnormal expression of the GnRH-R; e.g., overexpression, underexpression or expression or expression of a dysfunctional mutant receptor. Transgenic animals containing the GnRHR transgene may be used as animal models for the evaluation of GnRH analogs (in vivo).
Inventors:
Sealphone, Stuart See.
Application Number:
JP50253594A
Publication Date:
November 24, 2005
Filing Date:
June 22, 1993
Export Citation:
Assignee:
The Mount Sinai School of Medicine of the City University of New York
International Classes:
C12N15/09; A01K67/027; A61K35/14; A61K38/04; A61K39/00; A61K39/395; C07H21/04; C07K14/705; C07K14/72; C07K16/00; C07K16/28; C07K19/00; C12N5/10; C12N15/00; C12N15/113; C12N15/12; C12N15/62; C12N15/85; C12P19/34; C12P21/02; C12P21/06; C12P21/08; C12Q1/02; C12Q1/68; G01N33/53; G01N33/68; G01N33/76; A61K38/00; C12R1/91; (IPC1-7): C12N15/09; C07K14/72; C07K16/28; C07K19/00; C12N5/10; C12P21/02; C12P21/08; C12Q1/02; C12Q1/68
Other References:
Molecular Endocrinology, 1990, Vol.4, No.1, p.119-124
J.Biol.Chem., 1984, Vol.259, No.4, p.2031-2034
J.Biol.Chem., 1987, Vol.262, No.6, p.2895-2899
J.Biol.Chem., 1990, Vol.265, No.1, p.256-263
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Biochem.Biophys.Res.Commun.(1993), Vol.191, NO.3, p.1139-1144
Nature (1991), Vol.350, p.442-443
Oncogene (1987), Vol.1, p.277-283
Mol.Cell.Endocrinol.(1992), Vol.90, p.R5-R9
J.Biol.Chem., 1984, Vol.259, No.4, p.2031-2034
J.Biol.Chem., 1987, Vol.262, No.6, p.2895-2899
J.Biol.Chem., 1990, Vol.265, No.1, p.256-263
J.Mol.Endocrinol.(1988), Vol.1, No.3, p.9-12
J.Biol.Chem.(Oct. 1992), Vol.267, No.30, p.21281-21284
Biochem.Biophys.Res.Commun.(1992), Vol.189, No.3, p.1645-1652
Biochem.Biophys.Res.Commun.(1993), Vol.191, NO.3, p.1139-1144
Nature (1991), Vol.350, p.442-443
Oncogene (1987), Vol.1, p.277-283
Mol.Cell.Endocrinol.(1992), Vol.90, p.R5-R9
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Yasushi Hayakawa
Ishii Teiji
Yasushi Hayakawa