To provide isolated nucleic acid and amino acid sequences of CNG3B (a new cyclic nucleotide-gated cation channel), antibodies to CNG3B, methods of detecting CNG3B, and methods of screening for modulators of cyclic nucleotide-gated cation channels using biologically active CNG3B, and a method of screening for mutations of human CNG3B genes as well as a method for identifying a three-dimensional structure of human CNG3B polypeptides, in a computer system.
The invention provides an isolated nucleic acid encoding a polypeptide comprising a CNG3B subunit of a cation channel: (i) forming, with at least one additional alpha subunit, the cation channel having the characteristic of cyclic nucleotide-gating; and (ii) comprising a subsequence having at least 85% amino acid sequence identity to amino acids 210 to 661 in a specific sequence.
JEGLA TIMOTHY JAMES
JPN6014044284; 林健志編， 「実験医学別冊 バイオマニュアルＵＰシリーズ ＰＣＲ法の最新技術」， 第３刷， 株式会社羊土社， （１９９６）
JPN6014044285; Ｍ．Ａ．イニス外編，「ＰＣＲ実験マニュアル」， 初版， ＨＢＪ出版局， （１９９１）， ｐ．３５-４０
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima
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