Title:
コルヒチン誘導体
Document Type and Number:
Japanese Patent JP5829520
Kind Code:
B2
Abstract:
Provided are 4-modified colchicine compounds and medicines using the same. Specifically provided are colchicine derivatives represented by general formula (1), salts thereof, and solvates of the same. In general formula (1), R1 is a halogen atom, a hydroxyl group, a nitro group, an amino group, or a mono-, di- or tri-fluoromethyl group; R2, R3 and R4 are each a methoxy group or a hydroxyl group, or alternatively R2 and R3, or R3 and R4 together represent a methylenedioxy group; R5 and R6 may be the same or different and are each a hydrogen atom, a C1-6 alkyl group, an arylalkyl group, a C2-6 alkenyl group, -COR7, -COOR8, -SO2R9, -CONR10R11, or -CSNR12R13, or alternatively R5 and R6 together with the nitrogen atom to which R5 and R6 are bonded may form a three- to seven-membered cyclic amino group; R7 is a C1-6 alkyl group or the like; R8 is a C1-6 alkyl group or the like; R9 is a C1-6 alkyl group or the like; R10 and R11 may be the same or different and are each a hydrogen atom, a C1-6 alkyl group, or the like; and R12 and R13 may be the same or different and are each a hydrogen atom, an alkyl group, or the like.
More Like This:
Inventors:
Takamitsu Hiromitsu
Naoko Hachiho
Mariko Kitajima
Takashi Yaegashi
Ken Matsuzaki
Masato Nagaoka
Shusuke Hashimoto
Hiroyuki Nishiyama
Takuya Sugimoto
Masahiro Ono
Naoko Hachiho
Mariko Kitajima
Takashi Yaegashi
Ken Matsuzaki
Masato Nagaoka
Shusuke Hashimoto
Hiroyuki Nishiyama
Takuya Sugimoto
Masahiro Ono
Application Number:
JP2011527589A
Publication Date:
December 09, 2015
Filing Date:
August 20, 2010
Export Citation:
Assignee:
National University Corporation Chiba University
Yakult Honsha Co., Ltd.
Yakult Honsha Co., Ltd.
International Classes:
C07C225/20; A61K31/135; A61K31/165; A61K31/17; A61K31/18; A61K31/36; A61K31/397; A61K31/415; A61K31/4164; A61K31/4196; A61K31/42; A61K31/425; A61K31/4406; A61K31/4453; A61K31/495; A61K31/4995; A61K31/50; A61K31/505; A61K31/54; A61P35/00; A61P43/00; C07C229/14; C07C233/03; C07C233/32; C07C233/41; C07C233/61; C07C233/76; C07C235/14; C07C235/54; C07C237/04; C07C237/38; C07C255/57; C07C271/24; C07C271/56; C07C271/64; C07C275/26; C07C311/07; C07C311/13; C07C311/20; C07C317/28; C07C317/44; C07C321/14; C07C321/28; C07C323/52; C07C335/14; C07D211/58; C07D211/66; C07D213/73; C07D231/02; C07D233/54; C07D235/04; C07D237/06; C07D239/32; C07D241/10; C07D249/02; C07D261/02; C07D277/20; C07D277/62; C07D295/10; C07D295/18; C07D317/44; C07D319/14
Foreign References:
| WO2002100824A1 | 2002-12-19 | |||
| FR1512320A | 1968-02-09 |
Other References:
JPN6010064736; Ｊｏｕｒｎａｌ ｏｆ Ｌａｂｅｌｌｅｄ Ｃｏｍｐｏｕｎｄｓ ａｎｄ Ｒａｄｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｖｏｌ．５２, 2008, ｐ．１-５
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto