Title:
VEGF受容体阻害剤と他の治療剤の組み合わせ
Document Type and Number:
Japanese Patent JP2007505939
Kind Code:
A
Abstract:
The invention relates to a combination therapy for treating patients suffering from diseases characterized by cell proliferation and infiltration of inflammatory cells, coronary diseases, hypertension, renal diseases, diabetes, or ocular diseases and conditions. The patient is treated with a combination of: (a) a VEGF inhibitor compound; and (b) one or more second therapeutic agents selected from the group consisting of: i. angiostatic steroids; ii. photosensitizers; iii. implants containing corticosteroids; iv. AT1 receptor antagonists; V. ACE inhibitors; vi. cyclooxygenase inhibitors; vii. IGF-IR inhibitors; viii. mTOR kinase inhibitors; ix. somatostatin receptor antagonists; X. P13K inhibitors; A. Raf kinase inhibitors; xii. PKC inhibitors; xiii. integrin antagonists; xiv. endogenous anti-anglogenic molecules; and xv. PEDF and analogs.
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Inventors:
Guido Bolt
Josef Bernhard Brueggen
Jerry Min-Jean Juan
Frederick Ray Kinder Jr.
Heidi Rahne
Elisabeth Jeanne Latour
Paul William Manly
Janet Marjorie Wood
Josef Bernhard Brueggen
Jerry Min-Jean Juan
Frederick Ray Kinder Jr.
Heidi Rahne
Elisabeth Jeanne Latour
Paul William Manly
Janet Marjorie Wood
Application Number:
JP2006527355A
Publication Date:
March 15, 2007
Filing Date:
September 23, 2004
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
A61K45/06; A61K31/502; A61P1/04; A61P1/16; A61P3/00; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P9/14; A61P11/00; A61P11/06; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P25/00; A61P27/00; A61P27/02; A61P27/06; A61P27/10; A61P29/00; A61P35/00; A61P37/06; A61P41/00; A61P43/00; C07D401/06
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Mitsutaka Iwasaki