Title:
幹細胞動員に有用な医薬の組み合わせ
Document Type and Number:
Japanese Patent JP4855253
Kind Code:
B2
Abstract:
Combined pharmaceutical preparation containing G-CSF and P1GF as the active substances, are useful in the mobilization of blood stem cells in a patient or subject in need thereof.
Inventors:
Gianni, Alessandro Massimo
Carlo-stella, carmelo
Colotta, Francesco
Carlo-stella, carmelo
Colotta, Francesco
Application Number:
JP2006521487A
Publication Date:
January 18, 2012
Filing Date:
July 23, 2004
Export Citation:
Assignee:
Dompe Fa.le.Ma Sochieta per Azioni
International Classes:
A61K38/22; A61K38/18; A61K38/19; A61P7/00; A61P35/00; A61P37/00; A61P41/00
Other References:
KADAR,J.G. et al,Technical and safety aspects of blood and marrow transplantation using G-CSF mobilized family donors,Transfus Sci,1996年,Vol.17, No.4,p.611-8
DE,R.E. et al,Effects of granulocyte colony-stimulating factor and stem cell factor, alone and in combination, on the mobilization of peripheral blood cells that engraft lethally irradiated dogs,Blood,1994年,Vol.83, No.12,p.3795-9
CARLO-STELLA,C. et al,Defibrotide in combination with granulocyte colony-stimulating factor significantly enhances the mobilization of primitive and committed peripheral blood progenitor cells in mice,Cancer Res,2002年,Vol.62, No.21,p.6152-7
HATTORI,K. et al,Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment,Nat Med,2002年,Vol.8, No.8,p.841-9
CARMELIET,P. et al,Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions,Nat Med,2001年,Vol.7, No.5,p.575-83
DE,R.E. et al,Effects of granulocyte colony-stimulating factor and stem cell factor, alone and in combination, on the mobilization of peripheral blood cells that engraft lethally irradiated dogs,Blood,1994年,Vol.83, No.12,p.3795-9
CARLO-STELLA,C. et al,Defibrotide in combination with granulocyte colony-stimulating factor significantly enhances the mobilization of primitive and committed peripheral blood progenitor cells in mice,Cancer Res,2002年,Vol.62, No.21,p.6152-7
HATTORI,K. et al,Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment,Nat Med,2002年,Vol.8, No.8,p.841-9
CARMELIET,P. et al,Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions,Nat Med,2001年,Vol.7, No.5,p.575-83
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita