ヒストンデアセチラーゼ阻害剤と細胞死受容体リガンドの組み合わせ

Japanese Patent JP2007505860

A

The invention relates to a method of preventing or treating proliferative diseases such as cancer in a mammal, particularly a human, with a combination of pharmaceutical agents which comprises: (a) an HDAI; and (b) a death receptor ligand. The invention further relates to pharmaceutical compositions comprising: (a) an HDAI; (b) death receptor ligand; and (c) a pharmaceutically acceptable carrier. The present invention further relates to a commercial package or product comprising: (a) a pharmaceutical formulation of an HDAI; and (b) a pharmaceutical formulation of death receptor ligand for simultaneous, concurrent, separate or sequential use.

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Peter Wisdom Ataja
Kapil N Rose

JP2006526597A

March 15, 2007

September 17, 2004

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NOVARTIS AG

A61K45/00; A61K31/00; A61K31/343; A61K31/404; A61K38/19; A61K39/395; A61K45/06; A61P35/00; A61P35/02; A61P43/00; C07C259/06

WO2002022577A2

2002-03-21

Aoyama Aoi
Mitsutaka Iwasaki

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