Combination of local and systemic immunomodulatory therapies for improved cancer treatment

Japanese Patent JP6322413

B2

A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic immunomodulatory anticancer agent. A further method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic targeted anticancer agent. The present invention is further directed to pharmaceutical compositions for treatment of cancer. The intralesional chemoablative pharmaceutical composition can comprise an IL chemoablative agent comprising primarily a halogenated xanthene.

Craig Jay Eagle
Craig H. Dees
Eric A. Wakuta
Jamie Singer

JP2013557888A

May 09, 2018

March 09, 2012

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Provectas Pharma Tech, Ink.
Pfizer Inc.

A61K45/06; A61K31/352; A61K39/395; A61P35/00; A61P35/04; A61P43/00; A61K39/00

WO2010081173A2
WO2011011027A1

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Makoto Hagiwara

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