COMBINATION OF PDGF, KGF, IGF, AND IGFBP FOR WOUND HEALING

Title:

COMBINATION OF PDGF, KGF, IGF, AND IGFBP FOR WOUND HEALING

Document Type and Number:

Japanese Patent JP2007182461

Kind Code:

A

Abstract:

To provide an improved pharmaceutical composition for treating or preventing the damage of epithelial tissues, and to provide an improved method for the treatment and prevention.

This pharmaceutical composition for repair of epithelial tissues comprising a first polypeptide having the biological activity of a platelet-derived growth factor (PDGF) and a second polypeptide having the biological activity of keratinocyte growth factor (KGF). The pharmaceutical composition for repair of epithelial tissues, wherein the first polypeptide comprises a full-length PDGF polypeptide. The pharmaceutical composition, wherein the first polypeptide comprises a biologically active fragment of a full-length PDGF polypeptide. The pharmaceutical composition, wherein the first polypeptide comprises one selected from the group consisting of PDGF A chain and PDGF B chain.

Inventors:

WILLIAMS LEWIS T

Application Number:

JP2007104234A

Publication Date:

July 19, 2007

Filing Date:

April 11, 2007

Export Citation:

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Assignee:

CHIRON CORP

International Classes:

A61K38/22; A61K31/00; C12N15/09; A61K38/18; A61K38/27; A61K38/30; A61P17/00; A61P17/02; C07H21/04; C07K14/49; C12N15/12; C12N15/16; A61K38/00; A61K48/00

Domestic Patent References:

JPH01500199A	1989-01-26
JPS63119682A	1988-05-24

Foreign References:

WO1994016723A2	1994-08-04
WO1994004030A1	1994-03-03
WO1993021908A1	1993-11-11
WO1994023032A1	1994-10-13

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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