Title:
ワクチン接種とＰＤ−１経路の阻害との組み合わせ
Document Type and Number:
Japanese Patent JP6768045
Kind Code:
B2
Abstract:
The present invention relates to a vaccine/inhibitor combination comprising an RNA vaccine comprising at least one RNA comprising at least one open reading frame (ORF) coding for at least one antigen and a composition comprising at least one PD-1 pathway inhibitor, preferably directed against PD-1 receptor or its ligands PD-L1 and PD-L2. The present invention furthermore relates to a pharmaceutical composition and a kit of parts comprising the components of such a vaccine/inhibitor combination. Additionally the present invention relates to medical use of such a vaccine/inhibitor combination, the pharmaceutical composition and the kit of parts comprising such a vaccine/inhibitor combination, particularly for the prevention or treatment of tumor or cancer diseases or infectious diseases. Furthermore, the present invention relates to the use of an RNA vaccine in therapy in combination with a PD-1 pathway inhibitor and to the use of a PD-1 pathway inhibitor in therapy in combination with an RNA vaccine.
Inventors:
Fotin-Murejec, Mariola
Karen, Carl-Joseph
Probst, Jochen
Karen, Carl-Joseph
Probst, Jochen
Application Number:
JP2018190228A
Publication Date:
October 14, 2020
Filing Date:
October 05, 2018
Export Citation:
Assignee:
Cure Back Age
International Classes:
A61K31/7105; A61K39/00; A61K39/395; A61K47/42; A61P35/00; A61P43/00
Domestic Patent References:
| JP2012229213A | ||||
| JP2012502074A | ||||
| JP2012510619A |
Other References:
The Journal of Gene Medicine,2012年,Vol.14,p.428-439
Attorney, Agent or Firm:
Harakenzo world patent & trademark