Title:
患者における転移性癌の有効な治療のための組合せ
Document Type and Number:
Japanese Patent JP6831853
Kind Code:
B2
Abstract:
The present invention relates to methods and sets of drugs for the effective treatment of metastatic cancer and the administration of a set of drugs that overcome mechanisms of resistance to DNA-damaging agents, thereby sensitizing cancer cells to said DNA-damaging agents. The methods involve the administration of a set of drugs comprising melphalan, BCNU, hydroxocobalamin, and ascorbic acid. In a preferred embodiment, ethanol is also added to the set of drugs and bone marrow toxicity is reversed with an infusion of bone marrow stem cells. The methods also involve the depletion of GSH in tumors and the selective delivery of drugs to solid tumors. The methods also involve preventing the loss of catalase function and preventing oxidant-induced hemolysis and/or methemoglobin formation in subjects treated with oxidant drugs or agents that generate hydrogen peroxide, wherein said methods comprise the systemic administration of ethanol.
Inventors:
Arnold
Application Number:
JP2018549135A
Publication Date:
February 17, 2021
Filing Date:
December 06, 2016
Export Citation:
Assignee:
General Oncology, Incorporated
International Classes:
A61K31/714; A61K31/045; A61K31/175; A61K31/198; A61K31/375; A61K35/15; A61K45/06; A61P35/04; A61P43/00
Domestic Patent References:
| JP2005521053A | ||||
| JP2003501488A |
Foreign References:
| US20150265641 |
Other References:
V S. Akatov et al.,Combined vitamins B12b and C induce the glutathione depletion and the death of epidermoid human larynx carcinoma,Bioscience Reports,2000年,20(5),411-417
M E. Solovieva et al.,Vitamin B12b increases the cytoyoxicity of short-time exposure to ascorbic acid, inducing oxidative burst and iron-dependent DNA damage,Europian Journal of Pharmacology,2007年,566(1-3),206-214
V. S. Akatov et al.,Oxidative stress in HEp-2 human laryngel carcinoma cells induced by combination of vitamins B12 and C,Bulletin of Experimental Biology and Medicine,2003年,136(3),279-282
M. E. Poydock et al.,Growth-inhibiting effect of hydroxocobalamin and L-ascorbic acid on two solid tumors,IRCS Medical Science,1984年,12(9),813
M. E. Poydock et al.,Influence of Vitamines C and B12 on the survival rate of mice bearing ascites tumor,Expl Cell Biol,1982年,50,88-91
H F. Pierson,Depletion of extracellular cysteine with hydroxocobalamin and ascorbate in experimental murine cancer chemotherapy,Cancer Research,1985年,45,4727-4731
AI Chen et al.,Tandem chemo-mobilization followed by high-dose melphalan and carmustine with single autologous hematopoietic cell transplantation for multiple myeloma,Bone Marrow Transplantation,2012年,47,516-521
M E. Solovieva et al.,Vitamin B12b increases the cytoyoxicity of short-time exposure to ascorbic acid, inducing oxidative burst and iron-dependent DNA damage,Europian Journal of Pharmacology,2007年,566(1-3),206-214
V. S. Akatov et al.,Oxidative stress in HEp-2 human laryngel carcinoma cells induced by combination of vitamins B12 and C,Bulletin of Experimental Biology and Medicine,2003年,136(3),279-282
M. E. Poydock et al.,Growth-inhibiting effect of hydroxocobalamin and L-ascorbic acid on two solid tumors,IRCS Medical Science,1984年,12(9),813
M. E. Poydock et al.,Influence of Vitamines C and B12 on the survival rate of mice bearing ascites tumor,Expl Cell Biol,1982年,50,88-91
H F. Pierson,Depletion of extracellular cysteine with hydroxocobalamin and ascorbate in experimental murine cancer chemotherapy,Cancer Research,1985年,45,4727-4731
AI Chen et al.,Tandem chemo-mobilization followed by high-dose melphalan and carmustine with single autologous hematopoietic cell transplantation for multiple myeloma,Bone Marrow Transplantation,2012年,47,516-521
Attorney, Agent or Firm:
Yoshinori Hosoda