Title:
ウロテンシンIIとソマトスタチン5受容体に対するリガンドの活性基に対する組み合わせ足場アプローチ
Document Type and Number:
Japanese Patent JP2006520328
Kind Code:
A
Abstract:
The present invention provides a combinatorial approach to a library of novel compounds having four diversity points. The compounds provide for the mapping of urotensin II and somatostatin 5 receptors by differential binding of said receptors. The present invention further relates to a method of treating diseases for which modulation of the urotensin II receptor produces a physiologically beneficial response in said disease, such as those associated with CNS function and cardiovascular diseases. The present invention further relates to pharmaceutical compositions comprising these agents for the treatment of these diseases adapted to modulate the urotensin II receptor.
Inventors:
Olson, Roger
Application Number:
JP2006503667A
Publication Date:
September 07, 2006
Filing Date:
February 18, 2004
Export Citation:
Assignee:
Acadia Pharmaceuticals, Inc.
International Classes:
C07C225/18; A61K31/137; A61K31/415; A61K31/505; A61K31/513; A61K31/554; A61P9/02; A61P9/04; A61P9/12; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P25/02; A61P25/16; A61P25/18; A61P25/20; A61P25/28; A61P31/04; A61P43/00; C07C221/00; C07D231/06; C07D239/22; C07D239/26; C07D281/10
Attorney, Agent or Firm:
Takao Suzuki
Koichi Kajisaki
Yuzo Ozaki
Toshihiko Taniguchi
Koichi Kajisaki
Yuzo Ozaki
Toshihiko Taniguchi