Title:
急性骨髄性白血病の併用処置
Document Type and Number:
Japanese Patent JP2021511352
Kind Code:
A
Abstract:
本発明は、急性骨髄性白血病（ＡＭＬ）に罹患している患者を処置するための、ＢＥＴ阻害剤またはその薬学的に許容される塩もしくはその水和物と併用した、ボラセルチブまたはその薬学的に許容される塩もしくはその水和物の使用に関する。
Inventors:
Tonchu-Grund Ulrique
Baum Anke
Rudolph Dorothea Ingrid
Baum Anke
Rudolph Dorothea Ingrid
Application Number:
JP2020540571A
Publication Date:
May 06, 2021
Filing Date:
January 24, 2019
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07D487/04; A61K31/4439; A61K31/444; A61K31/4985; A61K31/501; A61K31/519; A61K31/52; A61K31/5377; A61K31/551; A61K31/5517; A61K45/00; A61P35/02; A61P43/00
Domestic Patent References:
| JP2015537021A | 2015-12-24 | |||
| JP2017517565A | 2017-06-29 | |||
| JP2016530259A | 2016-09-29 | |||
| JP2016540742A | 2016-12-28 | |||
| JP2015531365A | 2015-11-02 | |||
| JP2017529358A | 2017-10-05 |
Other References:
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NIETO-JIMENEZ, C. ET AL: "Targeting basal-like breast tumors with bromodomain and extraterminal domain (BET) and polo-like kin", ONCOTARGET, vol. 8, no. 12, JPN6022053855, 2017, pages 19478 - 19490, XP002789908, ISSN: 0004949512
MIRGUET, O. ET AL: "Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibit", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, JPN6022053856, 2013, pages 7501 - 7515, XP055171468, ISSN: 0004949513, DOI: 10.1021/jm401088k
ALBRECHT, B. K. ET AL: "Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, JPN6022053857, 2016, pages 1330 - 1339, XP055439635, ISSN: 0004949514, DOI: 10.1021/acs.jmedchem.5b01882
Attorney, Agent or Firm:
Shinichiro Tanaka
▲吉▼田 和彦
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Matsuda Nanae
▲吉▼田 和彦
Hiroyuki Suda
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Matsuda Nanae