Title:
Composition of Sitagliptin
Document Type and Number:
Japanese Patent JP6199556
Kind Code:
B2
Abstract:
The present invention relates to novel processes for the preparation of enantiomerically enriched β-amino acid derivatives such as β-amino esters useful for the synthesis of enantiomerically enriched biologically active molecules such as sitagliptin. The key step involves the resolution of the racemate with mandelic acid.
Inventors:
Gore, Vinayak Gobind
Gadakar, Maheshkumar
Bosale, Priyanka
Cinde, Slesh
Gadakar, Maheshkumar
Bosale, Priyanka
Cinde, Slesh
Application Number:
JP2012510370A
Publication Date:
September 20, 2017
Filing Date:
May 10, 2010
Export Citation:
Assignee:
Generics [OK] Limited
International Classes:
C07D487/04; A61K31/155; A61K31/192; A61K31/195; A61K31/216; A61K31/427; A61K31/4439; A61K31/4985; A61K31/64; A61K45/00; A61P3/04; A61P3/10; A61P9/12; A61P43/00
Domestic Patent References:
| JP2004536115A |
Other References:
TETRAHEDRON ASYMMETRY,2006年,V17 N2,P205-209
Hansen, Karl B.,et al.,First generation process for the preparation of the DPP-IV inhibitor sitagliptin,Organic Process Research and Development,2005年,vol.9 no.5,pp.634-639
分離技術、Vol.25、No.5、(1995)、p.375-380
Hansen, Karl B.,et al.,First generation process for the preparation of the DPP-IV inhibitor sitagliptin,Organic Process Research and Development,2005年,vol.9 no.5,pp.634-639
分離技術、Vol.25、No.5、(1995)、p.375-380
Attorney, Agent or Firm:
Fukami patent office