Title:
所定のキラリティーを有する化合物の合成
Document Type and Number:
Japanese Patent JPH09510716
Kind Code:
A
Abstract:
A method for synthesizing enantiomerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the alpha carbon. The chiral auxiliary can then be cleaved off, affording chiral end products useful for further transformations. The enantiomeric enrichment of the chiral end products may exceed 98%, and the chiral auxiliary can be recovered. Novel amides of pseudoephedrine used in this method are also disclosed.
Inventors:
マイヤーズ，アンドリユー・ジイ
Application Number:
JP52483595A
Publication Date:
October 28, 1997
Filing Date:
March 23, 1995
Export Citation:
Assignee:
カリフオルニア・インステイテユート・オブ・テクノロジー
International Classes:
B01J31/02; C07B53/00; C07C29/00; C07C29/147; C07C31/10; C07C31/125; C07C33/18; C07C33/34; C07C45/41; C07C45/45; C07C45/67; C07C47/02; C07C47/228; C07C49/04; C07C49/213; C07C49/76; C07C49/782; C07D521/00; C07C51/06; C07C53/126; C07C57/30; C07C227/18; C07C227/32; C07C231/12; C07C231/18; C07C233/17; C07C233/18; C07C233/22; C07C235/02; C07C235/34; C07C237/06; C07C237/16; C07C271/22; C07F7/18; C07F9/50; (IPC1-7): C07C233/18; B01J31/02; C07B53/00; C07C29/00; C07C31/10; C07C31/125; C07C33/18; C07C33/34; C07C45/41; C07C47/02; C07C49/04; C07C51/06; C07C57/30; C07C231/12; C07C233/22; C07D521/00; C07F9/50
Attorney, Agent or Firm:
川口 義雄 （外３名）