To obtain the subject cyclic dipeptide-containing composition that can improve stability of medicines, cosmetics, food products and the like, particularly their stability at a temperature near the body temperature by admixing a specific compound to these products.
1,3,5-Benzenetricarboxylic acid having the stereostructure responding to the compound to be prepared is allowed to react with thionyl chloride and the resultant acid chloride is allowed to react with the corresponding alkylamine or alkenylamine, and the product is purified, when necessary, to form an aspartic acid-phenylalanine cyclic dipeptide derivative of formula I [R is a 8-22C (cyclic structure-including) straight or branched alkyl or alkenyl] typically cyclo(L-β-dimethyloctylasparaginyl-L-phenylalanine). This compound is admixed to cosmetics, medicines and the like, particularly of high content of oily components. The amount of the compound of formula I is preferably 0.1-100 pts.wt. per 1 pt.wt. of the oily component.
MIKI TORU
SHIRAI HIROYOSHI
IYANAGI KOICHI
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