To provide a composition for keeping protuberance of epithelium, easily performable of injecting a solution through a fine catheter and capable of keeping the protuberance of the epithelium high.
The composition for keeping protuberance of epithelium comprises a solution comprising hyaluronic acid or a medically acceptable salt thereof, wherein (1) the solution has an apparent viscosity within a predetermined range when measured under predetermined conditions, (2) the force required for discharging the solution from the tip of a catheter injection needle by pressing the piston of the injector is within a predetermined range which injector is filled with the solution and holds the predetermined catheter injection needle, and (3), when administering the solution at a predetermined position of a rabbit stomach by a predetermined method, leaving 30 min, then quickly freezing the position and vertically cutting from the protuberance top, mucosal protuberance of the section is larger than the predetermined value.
MEYA JUNICHI
JP2001192336A | 2001-07-17 |
WO2002056914A1 | 2002-07-25 |