Title:
COMPOSITION AND METHOD FOR MODULATING IMMUNE RESPONSE
Document Type and Number:
Japanese Patent JP2012147786
Kind Code:
A
Abstract:
To provide a newly identified B7 receptor, zB7R1 that functions as a lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells.
The invention relates to a newly identified B7 receptor, zB7R1 that functions as a lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells, and also an identified CD155 as the counter structure of the zB7R1, Methods and compositions for modulating zB7R1-mediated negative signaling and interfering with the interaction of its counter-receptor for therapeutic, diagnostic and research purposes are also provided.
Inventors:
LEVIN STEVEN D
BILSBOROUGH JANINE
WEST JAMES W
BRANDT CAMERON
RAMSDELL FREDERICK J
HOWARD EDWARD D
CHADWICK ERIC M
GAO ZEREN
BILSBOROUGH JANINE
WEST JAMES W
BRANDT CAMERON
RAMSDELL FREDERICK J
HOWARD EDWARD D
CHADWICK ERIC M
GAO ZEREN
Application Number:
JP2012038077A
Publication Date:
August 09, 2012
Filing Date:
February 24, 2012
Export Citation:
Assignee:
ZYMOGENETICS INC
International Classes:
C12N15/09; A61K35/12; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P1/04; A61P35/00; A61P37/02; A61P37/06; C07K14/705; C07K16/28; C07K16/42; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C07K14/47; C12P21/08
Foreign References:
| WO2004024068A2 | 2004-03-25 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue