Title:
高脂血症、脂肪肝又は肥満の予防又は治療用組成物
Document Type and Number:
Japanese Patent JP5566384
Kind Code:
B2
Abstract:
Disclosed is a composition for prophylaxis or treatment of hyperlipidemia, fatty liver, cardiovascular disease or obesity including a compound represented by General Formula I as an effective ingredient:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ General Formula I €ƒ€ƒ€ƒS-(MS) p -(MS) q
wherein S represents sialic acid, and (MS) p and (MS) q independently represent a monosaccharide residue. The compound used as the effective ingredient induces body weight loss, decrease of organ fat, decrease of total cholesterol level, increase of HDL-cholesterol level, decrease of LDL-cholesterol level and decrease of leptin, and thereby provides prophylactic or therapeutic activity for hyperlipidemia, fatty liver, cardiovascular disease or obesity. Also, because it has no cytotoxicity or skin side effect, the provided composition may be safely used as a pharmaceutical composition, a neutraceutical composition or a food composition.
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Inventors:
Kang Seung Woo
Application Number:
JP2011521048A
Publication Date:
August 06, 2014
Filing Date:
July 31, 2009
Export Citation:
Assignee:
Benebiosis Company Limited
International Classes:
A61K31/702; A61K9/08; A61K9/10; A61K9/107; A61K9/127; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61P1/16; A61P3/06; A61P9/10; A61P9/12; C07H7/027
Domestic Patent References:
| JP10029945A | ||||
| JP2003292444A |
Other References:
GOSEKI-SONE,S. et al,Effects of dietary lactose on long-term high-fat-diet-induced obesity in rats,Obesity (Silver Spring),2007年,Vol.15, No.11,p.2605-13
NOHLE,U. et al,Metabolism of sialic acids from exogenously administered sialyllactose and mucin in mouse and rat,Hoppe Seylers Z Physiol Chem,1984年,Vol.365, No.12,p.1457-67
NOHLE,U. et al,Metabolism of sialic acids from exogenously administered sialyllactose and mucin in mouse and rat,Hoppe Seylers Z Physiol Chem,1984年,Vol.365, No.12,p.1457-67
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda