Title:
COMPOSITION FOR PROTECTING RETINAL NERVE CELLS CONTAINING PROCESSED BILBERRY FRUIT AND PROCESSED PINE BARK
Document Type and Number:
Japanese Patent JP2023009106
Kind Code:
A
Abstract:
To provide novel compositions that suppress nerve cell death, particularly retinal nerve cell death, and have retinal nerve cell-protecting and optic nerve-protecting effects.SOLUTION: A composition containing a processed bilberry fruit and a processed pine bark remarkably suppresses nerve cell death induced by various causes. Therefore, since the composition containing a processed bilberry fruit and a processed pine bark significantly suppresses nerve cell death, particularly retinal nerve cell death, it is expected to be useful as a composition for protecting retinal nerve cells or a composition for protecting optic nerve.SELECTED DRAWING: None
Inventors:
Kentaro Maki
Takasumi Taniguchi
Takasumi Taniguchi
Application Number:
JP2022175529A
Publication Date:
January 19, 2023
Filing Date:
November 01, 2022
Export Citation:
Assignee:
Santen Pharmaceutical Co., Ltd.
International Classes:
A61K36/45; A23L33/105; A61K36/15; A61P25/02; A61P27/02; A61P43/00
Domestic Patent References:
| JP2011509965A | 2011-03-31 |
Other References:
STEIGERWALT JR. ROBERT D, ET AL.: "Effects of mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects", MOLECULAR VISION, vol. 14, JPN6018048200, 2008, pages 1288 - 1292, XP002518335, ISSN: 0005167001
NAKAMURA ORIE ET AL.: "Bilberry extract administration prevents retinal ganglion cell death in mice via the regulation of c", CLINICAL OPHTHALMOLOGY, vol. 11, JPN6018048202, 12 September 2017 (2017-09-12), pages 1825 - 1834, ISSN: 0005167002
OSADA HIDETO ET AL.: "Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina", PLOS ONE, vol. 12(6)：e0178627, JPN6018048204, ISSN: 0005167003
OGAWA KENJIROU ET AL.: "The protective effects of bilberry and lingonberry extracts against UV light-induced retinal photore", J AGRIC FOOD CHEM, vol. 61, JPN6018048205, 2013, pages 10345 - 10353, ISSN: 0005167004
小川健二郎 他: "ビルベリー由来アントシアニンが目に与える機能性−ヒト臨床試験と機能性表示食品−", 岐阜薬科大学紀要, vol. 65, JPN6018048206, 2016, pages 20 - 27, ISSN: 0005167005
MATSUNAGA NOZOMU ET AL.: "Bilberry and its main constituents have neuroprotective effects against retinal neuronal damages in", MOL. NUTR. FOOD RES., vol. 53, JPN6018048208, 2009, pages 869 - 877, XP055590171, ISSN: 0005167006, DOI: 10.1002/mnfr.200800394
NAKAMURA ORIE ET AL.: "Bilberry extract administration prevents retinal ganglion cell death in mice via the regulation of c", CLINICAL OPHTHALMOLOGY, vol. 11, JPN6018048202, 12 September 2017 (2017-09-12), pages 1825 - 1834, ISSN: 0005167002
OSADA HIDETO ET AL.: "Neuroprotective effect of bilberry extract in a murine model of photo-stressed retina", PLOS ONE, vol. 12(6)：e0178627, JPN6018048204, ISSN: 0005167003
OGAWA KENJIROU ET AL.: "The protective effects of bilberry and lingonberry extracts against UV light-induced retinal photore", J AGRIC FOOD CHEM, vol. 61, JPN6018048205, 2013, pages 10345 - 10353, ISSN: 0005167004
小川健二郎 他: "ビルベリー由来アントシアニンが目に与える機能性−ヒト臨床試験と機能性表示食品−", 岐阜薬科大学紀要, vol. 65, JPN6018048206, 2016, pages 20 - 27, ISSN: 0005167005
MATSUNAGA NOZOMU ET AL.: "Bilberry and its main constituents have neuroprotective effects against retinal neuronal damages in", MOL. NUTR. FOOD RES., vol. 53, JPN6018048208, 2009, pages 869 - 877, XP055590171, ISSN: 0005167006, DOI: 10.1002/mnfr.200800394
Attorney, Agent or Firm:
Patent Attorney Corporation Tsukuni
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