Title:
COMPOSITION FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDER
Document Type and Number:
Japanese Patent JP2013035867
Kind Code:
A
Abstract:
To provide methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject.
Fat accumulation is increased or decreased, respectively by contacting a cell with a sirtuin activating compound or an inhibitory compound.
Inventors:
SINCLAIR DAVID A
ALEXANDER-BRIDGE MARIA
ALEXANDER-BRIDGE MARIA
Application Number:
JP2012222835A
Publication Date:
February 21, 2013
Filing Date:
October 05, 2012
Export Citation:
Assignee:
HARVARD COLLEGE
GEN HOSPITAL CORP
GEN HOSPITAL CORP
International Classes:
A61K31/05; A61K31/167; A61K31/17; A61K31/28; A61K31/343; A61K31/351; A61K31/353; A61K31/36; A61K31/381; A61K31/415; A61K31/4162; A61K31/42; A61K31/422; A61K31/426; A61K31/428; A61K31/4422; A61K31/444; A61K31/4709; A61K31/4743; A61K31/498; A61K31/517; A61K31/519; A61K31/5377; A61K31/5383; A61K31/549; A61K31/565; A61K31/65; A61K31/661; A61K31/704; A61K31/7048; A61P3/00; A61P3/04; A61P3/10; A61P43/00; C07D213/74; C07D217/26; C07D231/20; C07D241/42; C07D261/10; C07D263/34; C07D277/20; C07D277/34; C07D277/82; C07D307/84; C07D309/10; C07D317/60; C07D333/60; C07D401/06; C07D405/06; C07D409/04; C07D471/04; C07D487/04; C07D491/052; C07D495/20; C07D498/04; C07D513/04; C07D513/14; C07J19/00; C07J53/00
Domestic Patent References:
| JPH09143070A | 1997-06-03 | |||
| JP2002080362A | 2002-03-19 | |||
| JP2003524577A | 2003-08-19 |
Foreign References:
| WO2005002672A2 | 2005-01-13 | |||
| WO2005002527A2 | 2005-01-13 | |||
| WO2005026112A2 | 2005-03-24 |
Other References:
JPN6010073106; ＡＲＩＣＨＩ，Ｈ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔｓ ｏｆ ｓｔｉｌｂｅｎｅ ｃｏｍｐｏｎｅｎｔｓ ｏｆ ｔｈｅ ｒｏｏｔｓ ｏｆ Ｐｏｌｙｇｏｎｕｍ ｃｕｓｐｉｄａｔｕｍ Ｓｉｅｂ． ｅｔ Ｚｕｃｃ． ｏｎ ｌｉｐｉｄ ｍｅｔａｂｏｌｉ' Ｃｈｅｍ Ｐｈａｒｍ Ｂｕｌｌ （Ｔｏｋｙｏ） Ｖｏｌ．３０， Ｎｏ．５, 1982, ｐ．１７６６-７０
JPN6011052131; ＫＵＰＰＵＳＡＭＹ，Ｕ．Ｒ． ｅｔ ａｌ: 'Ｐｏｔｅｎｔｉａｔｉｏｎ ｏｆ ｂｅｔａ-ａｄｒｅｎｏｃｅｐｔｏｒ ａｇｏｎｉｓｔ-ｍｅｄｉａｔｅｄ ｌｉｐｏｌｙｓｉｓ ｂｙ ｑｕｅｒｃｅｔｉｎ ａｎｄ ｆｉｓｅｔｉｎ ｉｎ ｉｓｏｌａｔｅｄ ｒａ' Ｂｉｏｃｈｅｍ Ｐｈａｒｍａｃｏｌ Ｖｏｌ．４７， Ｎｏ．３, 1994, ｐ．５２１-９
JPN6011052133; ＫＵＰＰＵＳＡＭＹ，Ｕ．Ｒ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔｓ ｏｆ ｆｌａｖｏｎｏｉｄｓ ｏｎ ｃｙｃｌｉｃ ＡＭＰ ｐｈｏｓｐｈｏｄｉｅｓｔｅｒａｓｅ ａｎｄ ｌｉｐｉｄ ｍｏｂｉｌｉｚａｔｉｏｎ ｉｎ ｒａｔ ａｄｉｐｏｃｙｔｅｓ' Ｂｉｏｃｈｅｍ Ｐｈａｒｍａｃｏｌ Ｖｏｌ．４４， Ｎｏ．７, 1992, ｐ．１３０７-１５
JPN6011052135; ＩＷＡＳＨＩＴＡ，Ｋ．ｅｔ ａｌ: 'Ｅｆｆｅｃｔ ｏｆ Ｆｌａｖｏｎｏｉｄｓ ｏｎ ｔｈｅ Ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ｏｆ ３Ｔ３-Ｌ１ Ａｄｉｐｏｃｙｔｅｓ' Ｆｏｏｄ Ｓｃｉｅｎｃｅ ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｖｏｌ．７， Ｎｏ．２, 2001, Ｐ．１５４-１６０
JPN6011052131; ＫＵＰＰＵＳＡＭＹ，Ｕ．Ｒ． ｅｔ ａｌ: 'Ｐｏｔｅｎｔｉａｔｉｏｎ ｏｆ ｂｅｔａ-ａｄｒｅｎｏｃｅｐｔｏｒ ａｇｏｎｉｓｔ-ｍｅｄｉａｔｅｄ ｌｉｐｏｌｙｓｉｓ ｂｙ ｑｕｅｒｃｅｔｉｎ ａｎｄ ｆｉｓｅｔｉｎ ｉｎ ｉｓｏｌａｔｅｄ ｒａ' Ｂｉｏｃｈｅｍ Ｐｈａｒｍａｃｏｌ Ｖｏｌ．４７， Ｎｏ．３, 1994, ｐ．５２１-９
JPN6011052133; ＫＵＰＰＵＳＡＭＹ，Ｕ．Ｒ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔｓ ｏｆ ｆｌａｖｏｎｏｉｄｓ ｏｎ ｃｙｃｌｉｃ ＡＭＰ ｐｈｏｓｐｈｏｄｉｅｓｔｅｒａｓｅ ａｎｄ ｌｉｐｉｄ ｍｏｂｉｌｉｚａｔｉｏｎ ｉｎ ｒａｔ ａｄｉｐｏｃｙｔｅｓ' Ｂｉｏｃｈｅｍ Ｐｈａｒｍａｃｏｌ Ｖｏｌ．４４， Ｎｏ．７, 1992, ｐ．１３０７-１５
JPN6011052135; ＩＷＡＳＨＩＴＡ，Ｋ．ｅｔ ａｌ: 'Ｅｆｆｅｃｔ ｏｆ Ｆｌａｖｏｎｏｉｄｓ ｏｎ ｔｈｅ Ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ｏｆ ３Ｔ３-Ｌ１ Ａｄｉｐｏｃｙｔｅｓ' Ｆｏｏｄ Ｓｃｉｅｎｃｅ ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｖｏｌ．７， Ｎｏ．２, 2001, Ｐ．１５４-１６０
Attorney, Agent or Firm:
Mizuno Yuuki
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